PhD project

Supervised by Prof Evangelos Briasoulis

Run by Maria Igglezou

The use of circulating microRNAs as diagnostic and prognostic biomarkers 

The discovery of microRNAs has brought a new insight into the study of the regulation of gene expression in tumorigenesis.  There is strong evidence for the microRNA implication in cancer throughout all stages of the disease. Specific microRNAs (angiomirs) have been shown to modulate angiogenesis, key incident for the survival of neoplastic cells and tumor growth. Some microRNAs (oncomirs) have been further found to function as tumor suppressor genes and oncogenes. In the effort of making microRNA signatures a valid cancer classification tool with predictive and therapeutic value potential, the current project’s aiming to isolate and characterize circulating microRNAs from human blood and evaluate their overall clinical role as diagnostic and prognostic biomarkers. We also inquire the potential of human serum and plasma to constitute the starting material in a reliable and repeatable method to quantify microRNAs. 

Project list

Molecular mapping of microbial assemblages in aqueous ecosystems of Epirus and study of potential use as antineoplastic factors.

The last few decades many scientists are interested in exploring microbes’ communities in aqueous ecosystems. Freshwater microbial blooms have been shown to cause life threatening damages to human and animals. Microbial origin extracts, secondary metabolites and peptides have found application in everyday’s medicine as drugs and other active chemical compounds.The aim of the current project is to isolate, characterize and culture microbe cells growing in aqueous ecosystems as well as their extracts using molecular techniques, in order to study and better understand their role. In addition, methanol and aquatic extracts from bacteria will be evaluated for their potential cytotoxic and antineoplastic effects in vitro.

PhD project

Supervised by Dr Eustathios Friligos

Run by Anastasia Touka

This research Project  is co-funded by the European Union - European Social Fund (ESF) & National Sources, in the framework of the program “HRAKLEITOS II” of the “Operational Program Education and Life Long Learning” of the Hellenic Ministry of Education ,Life Long Learning  and religious affairs

Investigation of expression and predictive competency of membrane transporters in human blood cancers:

The last decade has brought many advances in the field of cancer research. A pivotal role in optimizing therapeutic yield in terms of achieving maximum efficiency at the cost of minimal toxicity is the identification of validated biomarkers. This research project aims to investigate the expression of well-characterized membrane transporters in blood cancers. Membrane transporters are important determinants of pharmacokinetics, safety and efficacy of many drugs. To date there are more than 400 characterized membrane transporters The results of this study is expected to contribute on the design of future clinical trials, and incorporate translational research on the intent to develop individualized therapies for patients with hematological cancers.

PhD project

Supervised by Prof Evangelos Briasoulis

Run by Lydia Kyriazopoulou MD