Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition. Int J Oncol 2015

Mavroeidis L., Sheldon H., Briasoulis E., Marselos M., Pappas P., Harris A.L

Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci USA 2015

Londin E., Loher P., Telonis A. G., Quann K., Clark P., Jing Y., Hatzimichael E., Kirino Y., Honda S., Lally M., Ramratnam B., Comstock C. E., Knudsen K. E., Gomella L., Spaeth G. L., Hark L., Katz L. J., Witkiewicz A., Rostami A., Jimenez S. A., Hollingsworth M. A., Yeh J. J., Shaw C. A., McKenzie S. E., Bray P., Nelson P. T., Zupo S., Van Roosbroeck K., Keating M. J., Calin G. A., Yeo C., Jimbo M., Cozzitorto J., R. Brody J., Delgrosso K., Mattick J. S., Fortina P., Rigoutsos I.

The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol Direct 2014

Londin E. R., Hatzimichael E., Loher P., Edelstein L., Shaw C., Delgrosso K., Fortina P., Bray P. F., McKenzie S. E., Rigoutsos I.

Kinetics o5 circulating levels of miR-195, miR-155 and miR-21 in patients with breast cancer undergoing mastectomy. Anticancer Res 2014

Igglezou M., Vareli K., Georgiou G. K., Sainis I., Briasoulis E.

Profile of pacritinib and its potential in the treatment of hematologic disorders. J Blood Med 2014

Hatzimichael E., Tsolas E., Briasoulis E.

How detection of epigenetic alterations of blood-borne DNA could improve melanoma diagnosis. Expert Rev Mol Diagn 2014

Hatzimichael E., Syed N., Nigro C. Lo, Rao B., Crook T.

Direct binding of Bcl-2 family proteins by quercetin triggers its pro-apoptotic activity. ACS Chem Biol. 2014

Primikyri A, Chatziathanasiadou MV, Karali E, Kostaras E, Mantzaris MD, Hatzimichael E, Shin JS, Chi SW, Briasoulis E, Kolettas E, Gerothanassis IP, Tzakos AG.

Impact of breast cancer surgery on angiogenesis circulating biomarkers: a prospective longitudinal study. World J Surg Oncol. 2013

Georgiou GK, Igglezou M, Sainis I, Vareli K, Batsis H, Briasoulis E, Fatouros M.

Novel oncology therapeutics: targeted drug delivery for cancer. J Drug Deliv. 2013

Tzakos AG, Briasoulis E, Thalhammer T, Jäger W, Apostolopoulos V.

Absence of BRAF exon 15 mutations in multiple myeloma and Waldenström's macroglobulinemia questions its validity as a therapeutic target in plasma cell neoplasias. Am J Blood Res. 2013

Hatzimichael E, Murray S, Briasoulis E.

Tumor-specific expression of organic anion-transporting polypeptides: transporters as novel targets for cancer therapy. J Drug Deliv. 2013

Buxhofer-Ausch V, Secky L, Wlcek K, Svoboda M, Kounnis V, Briasoulis E, Tzakos AG, Jaeger W, Thalhammer T.

Gene mutations and molecularly targeted therapies in acute myeloid leukemia. Am J Blood 2013 Jan

Hatzimichael E, Georgiou G, Benetatos L, Briasoulis E

Rb Part II cel cycler and cancer MOJ 2012 Nov

Ziouti F, Gbandi E, Hatzimichael E, Papanikolaou NA

The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma. Br J Cancer. 2012 Sep

Hatzimichael E, Lo Nigro C, Lattanzio L, Syed N, Shah R, Dasoula A, Janczar K, Vivenza D, Monteverde M, Merlano M, Papoudou-Bai A, Bai M, Schmid P, Stebbing J, Bower M, Dyer MJ, Karran LE, Elguetakarstegl C, Farrell PJ, Thompson A, Briasoulis E, Crook T.

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis. Cell Death Dis. 2012 Jul

Delage B, Luong P, Maharaj L, O'Riain C, Syed N, Crook T, Hatzimichael E, Papoudou-Bai A, Mitchell TJ, Whittaker SJ, Cerio R, Gribben J, Lemoine N, Bomalaski J, Li CF, Joel S, Fitzgibbon J, Chen LT, Szlosarek PW.

The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis. Cell Mol Life Sci. 2012 July

Benetatos L, Hatzimichael E, Londin E, Vartholomatos G, Loher P, Rigoutsos I, Briasoulis E.

A commitment to molecular oncology Mediterranean Oncology Journal, 2012 April

Briasoulis E, Murray S

NT5E CpG island methylation is a favourable breast cancerbiomarker Br J Cancer, 2012 April

Cristiana Lo Nigro, Martino Monteverde, Sonia Lee, Laura Lattanzio, Daniela Vivenza, Alberto Comino, Nelofer Syed, Angela McHugh, Hexiao Wang, Charlotte Proby, Ornella Garrone, Marco Merlano, Eleftheria Hatzimichael, Evangelos Briasoulis, Carlo Palmieri, Lee Jordan, Phil Quinlan, Alastair Thompson, Tim Crook    

NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity Br J Cancer, 2012 Mar 27

Wang H, Lee S, Nigro CL, Lattanzio L, Merlano M, Monteverde M, Matin R, Purdie K, Mladkova N, Bergamaschi D, Harwood C, Syed N, Szlosarek P, Briasoulis E, McHugh A, Thompson A, Evans A, Leigh I, Fleming C, Inman GJ, Hatzimichael E, Proby C, Crook T.

BIK (Bcl2-Interacting Killer) CpG methylation in multiple myeloma: a potential predictor of relapsed/refractory disease with therapeutic implications Leuk Lymphoma Jan 30 (2012)

Eleftheria Hatzimichael, Aggeliki Dasoula, Valentinos Kounnis, Leonidas Benetatos, Cristiana Lo Nigro, Laura Lattanzio, Alexandra Papoudou-Bai, George Dranitsaris, Evangelos Briasoulis, Tim Crook 

Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer. Oncotarget. 2012 January

Coley HM, Hatzimichael E, Blagden S, McNeish I, Thompson A, Crook T, Syed N.

Attitudes of people, authorities and doctors towards clinical cancer research: high expectations, neglected responsibilities and minimal involvement outline a hazy picture. Can we do any better? MOJ 2011:1;9-13

Hatzimichael E, Briasoulis E


Targeting oncogenic protein-protein interactions by diversity oriented synthesis and combinatorial chemistry approaches. Molecules 2011, 16(6):4408-4427.

Tzakos AG, Fokas D, Johannes C, Moussis V, Hatzimichael E, Briasoulis E

Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets. OncoTargets and Therapy 2011, 4:27-32.

Kounnis V, Ioachim E, Svoboda M, Tzakos A, Sainis I, Thalhammer T, Steiner G, Briasoulis E

Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs. Marine Drugs 2010, 8(3):629-657.

Sainis I, Fokas D, Vareli K, Tzakos AG, Kounnis V, Briasoulis E

Alterations of MicroRNAs in Solid Cancers and Their Prognostic Value. Cancers 2010, 2(2):1328-1353.

Chira P, Vareli K, Sainis I, Papandreou C, Briasoulis E

Molecular characterization of cyanobacterial diversity and yearly fluctuations of Microcystin loads in a suburban Mediterranean Lake (Lake Pamvotis, Greece). Journal of environmental monitoring : JEM 2009, 11(8):1506-1512.

Vareli K, Pilidis G, Mavrogiorgou MC, Briasoulis E, Sainis I

PPARgamma: The Portrait of a Target Ally to Cancer Chemopreventive Agents. PPAR research 2008, 2008:436489.

Sainis I, Vareli K, Karavasilis V, Briasoulis E

Contralateral prophylactic mastectomy: mind the genetics. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008, 26(11):1909-1910; author reply 1910.

Briasoulis E, Roukos DH

Molecular genetic tools shape a roadmap towards a more accurate prognostic prediction and personalized management of cancer. Cancer Biology & Therapy 2007, 6(3):308-312.

Roukos DH, Murray S, Briasoulis E

Individualized preventive and therapeutic management of hereditary breast ovarian cancer syndrome. Nature clinical practice Oncology 2007, 4(10):578-590.

Roukos DH, Briasoulis E

Publications - Presentations

23rd European Congress of Pathology, Helsinki, Finland 27.08.2011 - 01.09.2011

POSTER presentation

“Organic Anion Transporting Polypeptides 1A2, 1B1 and 1B3 are widely expressed in gastrointestinal and pancreatic cancers”

17th Hellenic Conference of Clinical Oncology, Athens, Greece 14.04.2011 – 16.04.2011

POSTER presentation

“Expression of organic anion-transporting polypeptides 1B3, 1B1 and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets” (in greek)

2011 Bi-annual Cyprus Anti-Cancer Society International Symposium, Limassol, Cyprus from 11-13 of March 2011

POSTER presentation

“Expression of organic anion-transporting polypeptides 1B3, 1B1 and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets”

22nd EORTC-NCI-MCR Symposium on Molecular Targets and Cancer Therapeutics, Berlin, Germany from the 16 -19 November 2010

POSTER presentation

“Investigations on Organic Anion-Transporting Polypeptides 1A2, 1B1 and 1B3 in Colon Cancer as Potential Targets for Cancer Therapy”

18th Postgraduate conference of Clinical Oncology, Heraklion, Crete, from 4 - 6 of November 2010.

ORAL presentation

“OATPs in digestive system cancers. Data from a comprehensive investigation of an independent therapeutic target”

ORAL presentation

“Security Aspects of DNA databases” by

Yannis Stamatiou

Assistant Professor, Dept. of Mathematics, University of Ioannina

and Research Academic Computer Technology Institute

Selected Publications

Selected Presentations

19th Postgraduate conference of Clinical Oncology, Heraklion, Crete, from 27 - 29 of October 2011.

ORAL presentation

Post-surgery kinetics of circulating 84 key genes involved in modulating the biological processes of angiogenesis in breast cancer patients undergoing mastectomy

(in greek)

36ο Συνέδριο Ελληνικής Εταιρίας Βιολογικών Επιστημών, Ιωάννινα 08 - 10 Μαΐου 2014

ORAL and POSTER presentations

"Μοριακή χαρτογράφηση των μικροβιακών κοινωτήτων στις αλπικές λίμνες της Ηπείρου" - Ελεονόρα Λιτή

"Νέα είδη/στελέχη αρχαίων και βακτηριών στα ιζήματα της λίμνης Παμβώτιδας" - Αναστασία Τούκα

"Μελέτη κυανοτοξινών στον Αμβρακικό κόλπο - μοριακή χαρτογράφηση τοξικών ειδών" - Μαρία-Χριστίνα Μαυρογιωργου

21th Postgraduate conference of Clinical Oncology, Heraklion, Crete, from. 7 -10 of November 2013

ORAL presentation 

“Perioperative kinetics of circulating microRNAs in patients undergoing mastectomy for breast cancer”

36th Scientific Conference of the Greek Society of Biological Sciences (EEBE), Ioannina, from 8 -10 of May 2014

ORAL presentation

“Pre-operative and post-operative expression levels of miR-195, miR-155 and miR-21 in breast cancer patients subjected to mastectomy”